A2M and targeted designed variants inhibit catabolic proteases in an ACLT rat model by Fluorescence

来源 :中华医学会第十八届骨科学术会议暨第十一届COA国际学术大会 | 被引量 : 0次 | 上传用户:woainiyuying
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  Since elevated levels of catabolic enzymes in synovial fluid induce chondrocyte death and cartilage matrix degeneration within one week of injury(1),early intervention strategies should focus on reducing these cartilage degrading proteases within a similar time frame.Previous studies have indicated that catabolic proteases and cytokines reach their peak within 48h after anterior cruciate ligament transection(ACLT),which initiates cell death and cartilage matrix degeneration(1).Thus,early intervention is critical to prevent Post-traumatic osteoarthritis(PTOA).
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