【摘 要】
：
The use of gemcitabine is limited,owing to its rapid metabolism by cytidine-deaminase and fast kidney excretion [1].A polymeric conjugate of gemcitabine was prepared by covalent coupling with poly (la
【机 构】
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Formulation and Drug Delivery Division,Indian Institute of Integrative Medicine,Jammu 180001,India
【出 处】
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The Third Symposium on Innovative Polymers for Controlled De
论文部分内容阅读
The use of gemcitabine is limited,owing to its rapid metabolism by cytidine-deaminase and fast kidney excretion [1].A polymeric conjugate of gemcitabine was prepared by covalent coupling with poly (lactic-co-glycolic) acid (PLGA) using DCC/NHS chemistry,in order to improve the anticancer properties of the drug.The synthesized conjugate was characterized by various analytical techniques including FTIR,NMR and mass spectroscopic analysis.The stability study indicated that the polymeric conjugate was more stable in plasma as compared to native gemcitabine.Further,the invitro cytotoxicity in a panel of cell lines including pancreatic cancer (MIAPaCa-2),breast cancer (MCF-7) and colon cancer (HCT-116),demonstrated that the cytotoxic activity of gemcitabine was retained following conjugation with the polymeric carrier.
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