【摘 要】
：
Fatty acid synthase (FAS) is emerging as apotential therapeutic target to treat cancer and obesity.In the course of searching forFAS inhibitory natural product,a MeOH extract of the aerial part of Sel
【机 构】
：
Chungnam National University Dep.Food and Nutrition,KOREA
论文部分内容阅读
Fatty acid synthase (FAS) is emerging as apotential therapeutic target to treat cancer and obesity.In the course of searching forFAS inhibitory natural product,a MeOH extract of the aerial part of Selaginella tamariscina (Selaginellaceae) exhibited significant inhibitory effect.Bioassay-guided fractionation and purification by using open column chromatography and HPLC afforded three active biflavonoids.They were identified as amentoflavone (1),hinokiflavone (2),and robustaflavone 7"-methyl ether (3) by analysis of NMR and MS data.Compounds 1,2 and 3 inhibited FAS activity with IC50 of 2.2 ± 0.4,13.5 ± 0.9,and 16.3 ± 0.3 mM,respectively.
其他文献
Over many decades the flavour industry has built up the ability to prepare flavours mimicking nature by using flavour ingredients that are isolated from natural sources like plants.Isolation of flavou
Fingerprinting technology has become a new tool for flavor analysis in complex matrixes,to detect overall product quality impacted by coherent effects of many constituents.In this paper,Sensor Array F
The colored strains of rice(red or black) as sources of anthocyanin were fed to rats to compare their effects on lipid metabolism and antioxidant activity in vivo.For experiment 1,male,Sprague Dawley
Peroxisomeproliferators-activated receptor α (PPARα),a member of the nuclear receptor superfamily,acts as a ligand-dependent transcription factor to regulate gene expression involved in lipid metaboli
This study was performed to investigate the chemical structure of novel compounds and anti-cancer activity of citric acid pretreated Korean red ginseng.Fresh ginseng was soaked in citric acid solution
With reference to the traditional use of Herbal medi-cines for relief of gastric and duodenal ulcer,plant extracts were screened for in vitro activity against Helicobacter pylori.Schizandra chinensis