Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkin

来源 :首都医科大学第四届研究生学术论坛第二分论坛 | 被引量 : 0次 | 上传用户:nocloud
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  Parkinsons disease (PD) is the second most common neurodegenerative disorder,but there are few treatments currently available.The autophagy pathway plays an important role in the pathogenesis of PD;modulating this pathway is considered to be a promising treatment strategy.Piperine (PIP) is a Chinese medicine with anti-inflammatory and antioxidant effects.The present study investigated the neuroprotective effects of PIP on rotenone-induced neurotoxicity in SK-N-SH cells,primary rat cortical neurons,and in a mouse model.
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