【摘 要】
：
Danhong injection (DHI), a Chinese Materia Medica standardized product extracted from Radix Salviae miltiorrhizae and Flos Carthami tinctorii, is effective in the treatment of atherosclerosis (AS)-rel
【机 构】
：
Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital Fudan University,180 Feng Lin Road,
【出 处】
：
第三届全国中西医结合脑心同治学术交流会
论文部分内容阅读
Danhong injection (DHI), a Chinese Materia Medica standardized product extracted from Radix Salviae miltiorrhizae and Flos Carthami tinctorii, is effective in the treatment of atherosclerosis (AS)-related diseases.It is widely recognized that AS is a complex inflammatory disease of the arterial wall and the dendritic cells (DCs) is a major player in the pathogenesis of AS via mediating atherosclerotic antigen presenting and T lymphocytes.Here, we determined the effect and possible mechanism of DHI on oxidized low-density lipoprotein (ox-LDL)-induced maturation and immune function of DCs.Human monocyte-derived DCs were incubated with DHI or ciglitazone and were subsequently stimulated with ox-LDL to induce maturation.Similar to ciglitazone, a peroxisome proliferator activated receptor (PPAR) γ agonist, DHI, could significantly reduce ox-LDL-induced expressions of mature markers, enhance the endocytotic function, and inhibit secretions of cytokine on DCs.These effects of DHI could be partly reversed by silencing the PPARγ.In conclusion, DHI could inhibit ox-LDL-induced maturation of DCs partly through activating a PPARγ-mediated signaling pathway.
其他文献
Hepatic veno-occlusive disease (HVOD) is a clinical syndrome characterized as hepatomegaly, ascites, jaundice and elevation of hepatic enzymes as an outcome from fibrous obliteration of small centrilo
Danhong injection (DHI) is the most prescribed injection form of Chinese medicine for the treatment of cardiovascular diseases such as atherosclerosis, angina pectoris, and stroke in China.However, it
Objective: To explore the synergistic protection of Danhong Injection (丹红注射液, DHI) and ischemic postconditioning on myocardial reperfusion injury in minipigs.Methods: Acute myocardial infarction model
糖尿病性脑卒中伴冠心病是糖尿病的主要的大血管并发症合并微血管并发症,自2010年以来运用脑心通联合脂必泰治疗2型DSCHD气虚兼痰瘀交阻证,并与肠溶阿司匹林联合阿托伐他汀钙对照组相比较,本研究显示补偿脑心通联合脂必泰治疗2型糖尿病性卒中并冠心病气虚兼痰疲交阻证中医疗效总有效率明显高于对照组，TC、HDL-C、UAER变化显著，心绞痛发作情况及各项指数变化均较对照组显著，中医症候积分除口渴外，其余均
积雪草(Centella asiatica[L] urban)性寒、味苦、辛,临床上用于传染性肝炎、急性肾小球肾炎,烧伤瘢痕等.为伞形科积雪草属植物,为多年生草本植物,干燥全草入药.又名雷公根、灯盏草、大金钱草、马蹄草等.野生资源丰富,多生长于海拔2000m以下的草地、沟边、田边等阴湿且土地肥沃处,全年可以采摘,广西壮族尤喜采用其消肿解毒、活血化瘀之功效治疗痧气腹痛、暑泻、湿热、疔痈肿毒、跌打损伤
冠心病是由于各种原因引起冠状动脉血管腔阻塞或痉挛,导致心肌缺血缺氧而引起的心脏病.近年多数学者支持"内皮损伤反应学说",认为本病主要危险因素最终都损伤动脉内膜,而粥样硬化病变的形成是动脉对内膜损伤作出的炎症-纤维增生性反应的结果.冠心病患者多由气虚而致,其最终病机多是血瘀.故益气活血为治疗冠心病的常用方法.脑心通胶囊是赵步长教授在补阳还五汤的基础上加味组成的,选用黄芪为君药,水蛭、地龙、全蝎为臣药
现代药理学研究结果显示,传统补益中药黄芪等具有增强机体免疫功能、耐缺氧及应激能力、促进机体代谢等药理作用.本研究在海拔4200m高原,通过对高原习服青年进行神经行为功能测试及自由基代谢生化指标检验,探讨步长脑心通胶囊对高原习服青年神经行为功能及代谢功能的影响.本次研究发现治疗组服药后较服药前NO,SOD增加，BLA减少;治疗组较对照组服药后NO,NOS,SOD增加，BLA减少，但没有发现MDA的明
步长丹红注射液(简称"丹红注射液")广泛应用于临床治疗脑心血管缺血性等疾病并取得满意疗效,且无毒性,不良反应发生率低(＜2‰),安全性高.介绍了丹红注射液药物组成和功能及用法，以及丹红注射液的质量检查，并叙述了丹红注射液治疗不稳定型心绞痛、稳定性心绞痛、极性脑梗死、椎-基底动脉供血不足、以及慢性肺源性心脏病急性加重期的临床应用。