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Folic acid (or folate,FA) has attracted considerable attention for cancer therapy.It is a small molecule whose receptor (folate receptor,FR) is significantly overexpressed on the surface of many human tumor cells compared with normal cells [1-3].Physical and chemical combined modification method was developed to modify FA and nanostructure on polydimethylsiloxane (PDMS) surface for possible application in microfluidic cytology [4-5].The surface property of differently treated PDMS was characterized by FTIR,AFM and contact angle measurement.AO/PI double staining,cell counting and MTT method were performed to examine the potential influence of FA modified nanopatterned PDMS on human cervical carcinoma (Hela) cell behavior.Both FA modification and nanostructure have a positive effect on the growth and viability of Hela cells.It is the first time that the small molecule-folic acid was used to immobilize on the surface of PDMS in order to improve the surface property.