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Objective: Inflammation has been shown to play a pivotal role in the pathogenesis and development of hypertensive vascular injury.Neopterin is a novel marker of immune activation produced mainly by activated macrophages.Few data are available to show the association between neopterin and vascular function in hypertension.The present study was designed to investigate the relationship between neopterin levels related to arterial stiffness and endothelial function in patients with hypertension, and their changes after blood pressure lowering treatment.