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Purpose:Inactivation of pl6 gene byCpG methylation is a frequent event in oral epithelial dysplasia.To investigate the predictive value of p16 methylation on malignant potential in oral epithelial dysplasia,we carried out the prospective cohort study.Experimental Design:One hundred one patients with histologicallyconfirmed mild or moderate oral epithelial dysplasia were included in the present cohort study.