Most tissues consist of multiple cell types.Global profiling of gene expression and methylation results from the convolution of multiple cell type specific expressions and methylations that lead to heterogeneity of molecular profiles.Heterogeneity of gene expression and methylation data is a major confounding factor in their analysis ignoring data heterogeneity leads to misleading results while recovering molecular components in the original subpopulations can identify the molecular structure of the tissue samples.In the last decade,there has been increasing interest in developing computational methods for deconvolution of gene expression and DNA methylation data.