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Objective: To investigate the effect of earlychronic tadalafil administration on erectile dysfunction after cavernous nerve (CN) injury in the rat model.Methods: Using the CN crush injury model,animals were divided into four groups: no CN injury (sham),bilateral CN injury exposed to either no tadalafil (control) or tadalafil at a dose (2 mg/kg) daily postoperation for 4 weeks,and normal group.