Thrombin-binding DNA aptamer(TBA)can fold into an G-quadruplex structure necessary for interacting with thrombin.It is reported that incorporation the D-isothymidine(D-isoT)or unlocked nucleic acid(UN
The primary barrier of eradicating HIV virus is the existence of latent reservoirs.So it is urgent to look for effective activators of latent HIV and find out the activate mechanisms.The positive tran
The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid(CD437/AHPN),which is RARγ agonist,can induces apoptosis in a number of malignant cell types [1-2].
Fragment-docking-oriented de novel design for the A,D and C site of protein tyrosine phosphatase 1B(PTP1B)and optimization led to the discovery of novel scaffold and chemical easy N-(2,5-diethoxy-phen
Aminopeptidase N(APN,EC 3.4.11.2)is highly expressed in tumor cells,and plays an essential role in tumor invasion,metastasis and angiogenesis.APN has been considered as a diagnostic or prognostic biom
Based on the strategy of “multifunctional drugs”,a novel series of phenylsulfonylfuroxan-based hydroxamates with histone deacetylase(HDAC)inhibitory and nitric oxide(NO)donating activities were design
Incorporating protein flexibility is a major challenge for docking-based virtual screening[1].With an increasing number of available crystal structures,ensemble docking with multiple protein structure