【摘 要】
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Owing to their unique characteristics,microelectrodes have attracted extensive research interests.Their small dimensions and high electron transport rates allow to measure biomolecule in microenvironm
【机 构】
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Division of Physical Biology & Bioimaging Center,Shanghai Synchrotron Radiation Facility,Shanghai In
【出 处】
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2016年分析化学前沿国际研讨会及中美分析化学研讨会
论文部分内容阅读
Owing to their unique characteristics,microelectrodes have attracted extensive research interests.Their small dimensions and high electron transport rates allow to measure biomolecule in microenvironment and facilitate the fast electrochemical monitoring process.In particular,it is critically important to miniaturize biosensors used in biological process.Ever since the first usage of carbon fiber microelectrodes(CFMEs)to monitor amine neurotransmitters in the brain by Adams group in 1976,CFMEs have been considered to be powerful tool to study electrophysiology process in brain.Here,based on the CFMEs we have developed low-noise nanometer-sized gold flower microelectrodes by electrochemical deposition.Using these gold flower microelectrodes,the detection limit of dopamine was low to 2.5 μM.In order to improve the biosensing performance,three types of gold flower electrodes with different sizes were developed.They all demonstrated improved sensing performance comparing to CFNEs.This experiment provided a facile technique to realize the secretion detection of a single cell.
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