2. 您的位置
3. 首页
4. 会议论文
5. Histone Deacetylase is Essential for Epigenetic Regulation of Thy-1 Gene Expression during Lipopolys

Histone Deacetylase is Essential for Epigenetic Regulation of Thy-1 Gene Expression during Lipopolys

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户：weiandlu

【摘 要】

：

Lipopolysaccharide (LPS)-induced proliferation of lung fibroblasts is closely correlated with loss of gene expression of thymocyte differentiation antigen-1(Thy-1), accompanied with deacetylation of h

【作 者】

：

Zhengyu He Yuxiao Deng Zhongwei Yang Qiaoyi Xu Wen Li Shunpeng Xing Xianyuan Zhao Ping Zhu Xiangrui Wang Yuan Gao 

【机 构】

：

Department of Critical Care Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong Univer

【出 处】

：

中国细胞生物学学会2015年全国学术大会

【发表日期】

：

2015年4期

【关键词】

：

lipopolysaccharide lung fibroblast histone deacetylase Thy-1 gene proliferation 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Lipopolysaccharide (LPS)-induced proliferation of lung fibroblasts is closely correlated with loss of gene expression of thymocyte differentiation antigen-1(Thy-1), accompanied with deacetylation of histones H3 and H4 at the Thy-1 gene promoter region;however, the mechanism remains enigmatic.

其他文献

The interplay between protein phosphatase 4 and scaffold attachement factor A plays an important rol

The scaffold attachment factor A (SAF-A) is required for kinetochore-microtubule attachment, and participates in prometaphase/metaphase transition.

会议

Protein phosphatase 4scaffold attachment factor Aprometaphase/metaphase transi

rBTI诱导乳腺癌MCF-7细胞凋亡的分子机制

乳腺癌是女性最常见的癌症之一.尽管早期诊断和治疗已经取得了很大进步,但它依然是女性癌症死亡的主要原因.研究发现,NF κ B/p65在乳腺癌细胞的发生和发展中起着关键的作用.养麦(Fagopyrum esculentum Moench.)作为一种药食同源的植物,目前在食品和医药方面有着广泛的应用.本课题组此前通过基因工程技术获得了高纯度重组荞麦胰蛋白酶抑制剂(recombinant buckwhe

会议

重组养麦胰蛋白酶抑制剂紫杉醇凋亡NFκB/p65MCF-7细胞

Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by

Surgery-induced inflammation has been associated with cancer recurrence and metastasis in colorectal cancer (CRC).As a constituent of gram-negative bacteria, lipopolysaccharide (LPS) is frequently abu

会议

PKM1PKM2STAT3LPSinflammationproliferation

Application of synthetic chondroitin sulfate (CS) binding peptides in primary mouse cerebellar granu

Chondroitin sulfate proteoglycans (CSPGs) are up-regulated in the microenvironment of the glial scar after spinal cord injury (SCI), as a key inhibitory factor for axon regeneration.Recent studies hav

会议

CSPGsbinding peptideneurite outgrowthcerebellar granule neurons (CGNs)

Live cell engulfment by entosis in human tumors

Human carcinomas are comprised of complex cell mixtures that undergo rapid evolution.Many tumors contain multiple intratumoral cell clones that likely compete indirectly for nutrients and growth facto

会议

Cooperative Actions of Protein Kinases to Orchestrate Chromosome Segregation in Mitosis

Histone modifications coordinate the chromatin localization of key regulatory factors in mitosis[1].For example, mitotic phosphorylation of Histone H3 threonine-3 (H3T3ph) by Haspin is required for ce

会议

MitosisHistone phosphorylationCentromereProtein kinaseHaspin

Apigenin inhibits pancreatic cancer through disrupting Hsp90/Cdc37 complex

Apigenin(4,5,7,-trihydroxyflavone) is a common non-mutagenic plant flavonoid widely distributed in vegetables and fruits that has a broad spectrum of anti-proliferative activities against many types o

会议

ApigeninHsp90Cdc37SRL-PFACPancreatic cancer

Programmed necrosis in host defense against HSV-1

The Receptor-interacting kinase-3 (RIP3) and its downstream substrate MLKL (mixed lineage kinase domain-like protein) have emerged as the key cellular components in programmed necrotic cell death.

会议

programmed necrosisHSV-1ICP6RIP3MLKL

PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon

The p2 l-activated kinase 5 (PAK5) is overexpressed in advanced cancer and the transcription factor E47 is a direct repressor of E-cadherin and inducer of epithelial-mesenchymal transition (EMT).

会议

E47PAK5EMTcolon cancermetastasis

GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signal

Epithelial-mesenchymal transition (EMT) is a key process in tumor metastatic cascade that is characterized by the loss of cell-cell junctions, resulting in the acquisition of migratory and invasive pr

会议

Breast cancerEMTGATA1PAK5PhosphorylationHDACs