Aim: This study aims to systematically investigate the effects of furanodiene (FUR), a natural terpenoid isolated from Rhizoma Curcumae, on cell viability and significant processes of tumor progression in 95-D lung cancer cells.Methods: MTT assay and flow cytometry were used to detect the anti-proliferative effects and cell cycle distribution, respectively.Western blot assay was performed to detect the expression of proteins related to the different cellular signal pathways.