Alzheimers disease (AD) is a multifactorial neurodegenerative condition which undergoes with neuroinflammatory responses[l].It has also been demonstrated that Ibuprofen prevents AD.However,Ibuprofen has limitations of low permeability trough the blood-brain barrier (BBB) and gastric side effects.To overcome these,the active enantiomer of Ibuprofen,Dexibuprofen (DXI),has been encapsulated into PLGA-PEG nanoparticles with a matrix structure (NSs).