【摘 要】
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Porcine reproductive and respiratory syndrome virus (PRRSV) causes continuous problems in the pig industry,due to high costs of outbreaks and reduced welfare of diseased pigs.The severity of infection
【机 构】
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Department of Infection Biology, Central Veterinary Institute, part of Wageningen UR, P.O.Box 65, 82
【出 处】
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2013国际猪繁殖与呼吸综合征学术研讨会
论文部分内容阅读
Porcine reproductive and respiratory syndrome virus (PRRSV) causes continuous problems in the pig industry,due to high costs of outbreaks and reduced welfare of diseased pigs.The severity of infection is,partly,dependent on the virus strain.Recently isolated Eastem European subtype 3 strains are more virulent than the widespread subtype 1 strains.There is,however,almost no information available about the mechanisms involved in the virulence of these subtype 3 strains.The objective of the present study was to characterize the in vitro and in vivo response of two European subtype 1 strains,Belgium A and Lelystad-Ter Huurne (LV),and a virulent subtype 3 strain,Lena,in dendritic cells (in vitro) and alveolar macrophages (in vitro and in vivo).It was shown that infection with the Lena strain resulted in a higher apoptosis of cells in vitro and a higher level of infectivity in vitro and in vivo than the other virus strains.
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