Synthesis of Novel Tetrazole-linked Carbazole Derivatives as Highly Potent Antimicrobial Agents

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：tianfong

【摘要】

：

Infectious diseases caused by microbes are a serious public safety issues associated with significant mortality and health-care costs in world-wide.Hence,the development of alternative novel drugs is

【作者】

：

Nagarajan SANGARAIAH Cheng-He ZHOU

【机构】

：

Institute of Bioorganic & Medicinal Chemistry,Key Laboratory of Applied Chemistry of Chongqing Munic

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Carbazole Tetrazole Antibacterial Antifungal

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Infectious diseases caused by microbes are a serious public safety issues associated with significant mortality and health-care costs in world-wide.Hence,the development of alternative novel drugs is essential with more potent “resistance-resistant” antimicrobial agents that would lead new modes of action and a broad spectrum of activities.

其他文献

Synthesis and process optimization of Vandetanib

Vandetanib(1)is a kind of tryrosine kinase inhibitors.It is a potent inhibitor of VEGF RTK and also has some activity against epidermal growth factor(EGF)RTK[1].It inhibits the effects of VEGF and is

会议

Vandetanibtryrosine kinase inhibitorSynthesis

Synthesis of N-(4-((1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-3-fluorophenyl)picolinamide derivatives as c-

c-Met is a proto-oncogene that encode a protien known as hepatocyte growth factor receptor(HGFR)[1].Inappropriate activity of c-Met can cause wide variety of different cancers such as breast,pancreas,

会议

c-Met inhibitorsSynthesisAntitumor activity

2-硫烷基-6-(4H-1,2,4-三唑-4-基)苯并[d]恶唑的合成及其抗癫痫和抗抑郁活性研究

会议

Oligothiophene compounds inhibit the membrane fusion of H5N1 avian influenza virus

Hemagglutinin(HA)which is essential for influenza viral infection and replication has become a target for the design of anti-influenza drugs.A novel series of oligothiophene compounds focused on the t

会议

multithiopheneH5N1 influenza virushemagglutinin(HA)fusion inhibitor

Design and Synthesis of Chiral Binaphthol-Derived Bisphosphoric Acids and Their Application in the C

Chiral BINOL-based phosphoric acids are an array of privileged and bifunctional organocatalysts,the activities of which have been successfully demonstrated in a variety of organic transformations.[1]

会议

asymmetric hydrogenationbinaptholsbisphosphoric acidsorganocatalysis

Synthesis and Antimicrobial activity of Novel Structural Coumarinazoles

Bacterial resistance continues to progress and pose a significant threat,both in hospitals and,more recently,in the community.

会议

CoumarinImidazoleAntibacterialAntifungal

Design and Synthesis of Novel Aminothiazolyl Quinolones

A series of novel 3-aminothiazolquinolones as newly structural antibacterial agents were designed and synthesized for the first time.

会议

QuinoloneAminothiazoleSynthesisAntibacterial

Bioactive Evaluation and Cytotoxicity of Quinolones with Metronidazole

Hybrids of metronidazole and quinolones as antimicrobial agents were developed and their bioactive assay that the newly synthesized compounds exhibited good or even stronger antimicrobial activities a

会议

QuinoloneMetronidazoleImidazoleDNAAntibacterial

Berberine-derived Benzimidazoles as New Potential Antimicrobial Agents:Design,Synthesis and Biologic

A series of novel berberine-derived benzimidazole derivatives and characterized by NMR,IR,MS and HRMS spectra.All the new compounds were screened for their antimicrobial efficacy against four Gram-pos

会议

BerberineBenzimidazoleAntibacterialMolecular docking

Bioactive Evaluation and Cytotoxicity of Naphthalimide Nitrogen Mustards

A series of naphthalimide nitrogen mustards as anticancer agents were developed,their structures were characterized by 1H NMR,13C NMR,IR,MS and HRMS spectra,and the single crystal of compound 4g was s

会议

NaphthalimideNitrogen mustardsynthesisAnticancerCytotoxicity

Synthesis of Novel Tetrazole-linked Carbazole Derivatives as Highly Potent Antimicrobial Agents

与本文相关的学术论文