Friedel-Crafts 反应是一类重要的有机合成反应,研究和开发新型高效的Friedel-Crafts 反应催化剂一直是科研工作者们关注的热点[1-2].本文研究了3 种单桥连双环戊二烯基双核铼羰基配合物E[(η5-C5H4)(CO)3]2 [E = C(CH3)2(1),C(CH2)5(2),Si(CH3)2(3)]用于苯甲醚与不同酰氯发生Friedel-Crafts 酰基化反应的催化活性
α-Amino ketones are important class of biologically active compounds in natural products and medicinal chemistry.They are also used as valuable intermediates to access 2-amino alcohols and diverse nit
近年来,以抗衡阴离子为导向的均相不对称催化(ACDC)引起人们的广泛关注.该类反应通过阳离子中间体与手性抗衡阴离子一起组成手性离子对催化剂,在不对称有机催化、过渡金属催化以及路易斯酸催化等方面均取得了成功[1].
3-Pyrrolines,also called 2,5-dihydropyrroles,present an important class of five-membered nitrogen-containing heterocycles due to their presence in natural and synthetic biologically active compounds.
氮杂环卡宾的N-取代基引入杂原子基团可以形成hemilabile 配体,氮杂环卡宾与金属形成稳定的M—C 键,既增加相应催化剂的稳定性又可以提高金属中心电子云密度,利于氧化加成,杂原子基团的弱配位作用有利于催化过程中的金属配体间的可逆缔合/解离过程,动态产生配位空位,生成配位不饱和活性中心,有利于反应底物与金属中心的络合,近年来,许多含P,N,O 和S 等杂原子官能团的氮杂环卡宾过渡金属化合物被国
The exhaled breath contains vital information on personal metabolic states,which makes the breath analysis attractive for non-invasive diagnosis.
The rich chemistry of diazo compounds has been extensively explored and has found useful applications in organic synthesis.
In order to grasp the molecular mechanisms and metabolic pathways of pathophysiological processes in tissues and other biological matrices it is often necessary to obtain information about different c
质谱的数据非依赖采集(DIA)通过连续且无偏差地获得所有化合物的MS、MS/MS 信息,可显著提高复杂样本的质谱分析效率,减少基质对代谢物定量分析的影响[1],[2]。
铂植入剂作为抗肿瘤长效制剂,可在组织器官中植入给药或外科术中给药,实现局部的药物高浓度及较小的周边血药浓度。抗肿瘤铂制剂在临床应用中可引起广泛的不良反应,通过监测血液铂含量以使药物长期维持在安全有效浓度范围之内,间接反映临床用药对生物组织器官的毒性反应,进而提供药动力学研究资料,做好不良反应的预防和处理,提高疗效并减轻毒副作用。