Background The use of vascular closure devices (VCDs) for the reduction of access site complications following percutaneous coronary intervention (PCI) remains controversial.Patients undergoing primary PCI for acute ST-segment elevation myocardial infarction (STEMI) are at high risk of femoral artery complications.A lack of information exists regarding the use of VCDs in this group of patients because they have been excluded from randomized trials.This study sought to evaluate the safety and efficacy of the use of VCDs after primary PCI.