【摘 要】
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Background: Memantine (MEM) is used for improving the cognitive impairments of the patients suffered from Alzheimers diseases (AD) by uncompetitive inhibition of N-methyl-d-aspartate (NMDA) receptor.M
【机 构】
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Department of Pharmacology,School of Pharmacy,China Medical University,Shenyang,P.R.China,110001
【出 处】
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中国药理学会麻醉药理专业委员会第五次学术年会
论文部分内容阅读
Background: Memantine (MEM) is used for improving the cognitive impairments of the patients suffered from Alzheimers diseases (AD) by uncompetitive inhibition of N-methyl-d-aspartate (NMDA) receptor.MEM exerts its neuroprotective effects via multiple mechanisms.However,it is still not clear whether nerve growth factor (NGF) signaling contributes to the mechanism of MEM.Aims: This study investigated the neuroprotective effects of MEM on cognitive performance and amyloidosis in APP/PS1 transgenic mice and determined the involvement of NGF signaling to the mechanism of MEM.
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