【摘 要】
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This study was aimed at evaluating the hypouricemic effect of the anthocyanin-rich purple sweet potato extract (APSPE).In vitro, APSPE was proved to signifi
【机 构】
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College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
【出 处】
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2015中国植物学会第十三届全国药用植物及植物药学术研讨会暨2015年海峡两岸中医药科学交流会
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This study was aimed at evaluating the hypouricemic effect of the anthocyanin-rich purple sweet potato extract (APSPE).In vitro, APSPE was proved to significantly inhibit XO activity in a dose-dependent manner.In vivo, APSPE could not only inhibit the XO activity in mouse liver, but also reduce the serum uric acid level in hyperuricemic mice and affect the expression of the mRNA levels of related renal transporters, such as mURAT1, mGLUT9,mOAT1 and mOCTN2.Moreover, APSPE could effectively regulate BUN and Cr levels to normal and decrease the inflammatory cellular influx in the tubule of the hyperuricemic mice.This study indicates the potential clinical utility of APSPE as a safe and effective anti-hyperuricemia bioactive agent or functional food.
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