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  5. Exendin-4 improves the survival and therapeutic efficacy of implanted stem cells following myocardia

Exendin-4 improves the survival and therapeutic efficacy of implanted stem cells following myocardia

来源 :第11届中国介入心脏病学大会 | 被引量 : 0次 | 上传用户：zhehong220
【摘 要】
：
Background The poor survival rate of stem cell transplantation in ischemic myocardial microenvironment is a major obstacle for stem cell therapy.Exendin-4 holds the potential of cardioprotective effec
【作 者】
：
LIU Jian-feng CHEN Yun-dai WANG Hai-bin LIU Zhi-qiang YANG Jun-jie TIAN Feng WANG Chang-yong 
【机 构】
：
Department of Cardiology,Chinese PLA General Hospital,Beijing,China
【出 处】
：
第11届中国介入心脏病学大会
【发表日期】
：
2013年7期
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Background The poor survival rate of stem cell transplantation in ischemic myocardial microenvironment is a major obstacle for stem cell therapy.Exendin-4 holds the potential of cardioprotective effect based on their pleiotropic activity.This study was designed to investigate whether the combination of exendin-4 and adipose derived stem cells (ADSCs)could significantly improve the stem cells survival, engraftment and contribute to myocardial repair after myocardial infarction.
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