【摘 要】
：
AIM: To probe the effects and the mechanism of Astragaloside Ⅳ and Ginsenoside Rg1 on autophagy of PC12 cell induced by oxygen glucose deprivation/reoxygenation(OGD/R).METHODS: The autophagy injury mo
【机 构】
：
Molecular Pathology Laboratory,Key Laboratory of Hunan Province for Prevention and Treatment of Inte
论文部分内容阅读
AIM: To probe the effects and the mechanism of Astragaloside Ⅳ and Ginsenoside Rg1 on autophagy of PC12 cell induced by oxygen glucose deprivation/reoxygenation(OGD/R).METHODS: The autophagy injury model of PC12 cell induced by OGD/R was established,the effect of Astragaloside Ⅳ combined with Ginsenoside Rg1 on autophagy was observed,the mechanism was studied through PI3K Ⅰ/Akt/m-TOR and PI3K Ⅲ/Becline-1/Bcl-2 signaling pathways.
其他文献
From androgenetic haploid blastocysts derived by injection of sperm into enucleated oocytes,we generate mouse androgenetic haploid embryonic stem cells(AG-haESCs)that can support full-term embryonic d
Spermatogonial stem cells(SSCs),namely male germline stem cells,are a subpopulation of type A spermatogonia capable of both self-renewing to maintain stem cell pool and differentiating into mature spe
A key step towards generating fertilization-competent eggs is the maturation of oocytes.Oocyte maturation encompasses integrated nuclear and cytoplasmic changes taking place during oocyte development,
Premature Ovarian Insufficiency(POI)is one of the most common reproductive disorders.However,the etiological causes of this disease still remain elusive.In this study,two novel mutations of WDR62 gene
Erythropoiesis is the process by which hematopoietic stem cells proliferate and differentiate through multiple stages to produce red cells.Dysregulation at any developmental stage will lead to anemia.
Germline activating mutations of protein tyrosine phosphatase PTPN11(Shp2),a positive regulator of the Ras signaling pathway,are associated with 50%of patients with Noonan syndrome.These patients have
Haematopoietic stem cells(HSCs)are derived early from embryonic precursors,such as haemogenic endothelial cells and pre-haematopoietic stem cells(pre-HSCs),the molecular identity of which still remain
The voltage sensor domain(VSD)consists of four transmembrane segments,serving as a voltage sensing module highly conserved among voltage-gated ion channels and voltage-sensing phosphatase(VSP).VSD-lik
Aim of study: To investigate the effects of the different proportion combinations between Astragalus and Angelica on bone marrow hematopoiesis suppression induced by Cyclophosphamide(CTX)in mice,furth
AIM: To probe the effect of Astragaloside Ⅳ and Ginsenoside Rg1 on autophagy injury of PC12 cell induced by oxygen glucose deprivation/reoxygenation(OGD/R),as well as their interactions.METHODS: The a