【摘 要】
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The clinical application of doxorubicin(DOX), an effective anti-cancer drug, has been limited by side effects, especially cardiotoxicity and nephrotoxicity which might be caused by reactive oxygen spe
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The clinical application of doxorubicin(DOX), an effective anti-cancer drug, has been limited by side effects, especially cardiotoxicity and nephrotoxicity which might be caused by reactive oxygen species(ROS) generated by DOX. To address the above limitations, co-loading DOX with ROS scavenger, like quercetin(Qu), is a smart strategy. In this investigation, quercetin-pending micelles based on boronic-ester coupling co-loaded DOX with Qu were made based on phenylboronic acid-catechol pending between dextrinethylenediamine-phenylboronic acid(Dex-(eda)-PBA) and Qu. DOX was encapsulated in the hydrophobic core of micelles via hydrophobic force. The ATP-responsive boronic-ester could not only enhance the stability of micelle under physiological condition, but also explosively release drug a
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