【摘 要】
：
This study observed the role of ERK1/2 in the myocardial fibrosis in cultured cardiac fibroblasts.After exposure to aldosterone(Ald) and ERK1/2 inhibitor PD98059, cell cycle, proliferation, P-ERK1/2 e
【机 构】
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Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050000,China
【出 处】
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International Conference for Physiological Sciences 2012(201
论文部分内容阅读
This study observed the role of ERK1/2 in the myocardial fibrosis in cultured cardiac fibroblasts.After exposure to aldosterone(Ald) and ERK1/2 inhibitor PD98059, cell cycle, proliferation, P-ERK1/2 expression of cells and collagen content in culture medium were measured by flow cytometry, MTT, Western blot and hydroxyproline content, respectively.Ald changed cell cycle, increased proliferation, P-ERK1/2 expression and collagen content, which were partly inhibited by PD98059.Our study suggested that ERK1/2 play a key role in the myocardial fibrosis induced by aldosterone in cultured cardiac fibroblasts.
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