【摘 要】
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Objective General anesthesia and natural sleep involve many obvious similarities.Some stimulatory neuropeptides such as orexin and neuropeptide S were reported to reduce anesthesia time, but relating
【机 构】
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Departments of Neuroscience,Anatomy,Histology,and Embryology,Key Laboratory of Preclinical Study for
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Objective General anesthesia and natural sleep involve many obvious similarities.Some stimulatory neuropeptides such as orexin and neuropeptide S were reported to reduce anesthesia time, but relating EEG profile changes were unknown.The present study aims to evaluate the effects of neuropeptide S and its cognate receptor (NPS-NPSR) system on sleep-waking profiles and cortical EEG power spectra in anesthetic-treated rats.Methods NPS with or without NPSR antagonist were administered intracerebroventricularly, then GABAA and NMDAreceptor types anesthetics propofol (50 mg/kg) and ketamine (100 mg/kg) were injected intraperitoneally.The change of sleep-wake profiles was assessed by sleep recordings and cortical EEG power spectra were analyzed by fast Fourier transform.ResultsNPS (1-2 nmol) significantly reduced the amount of propofol-induced slow wave sleep (SWS) and EEG delta activities.NPS (1-5 nmol) reduced the duration of ketamine-induced SWS characterized by EEG delta activities and significantly increased EEG theta activities.The inhibitory effect of NPS on anesthetics-induced SWS was through reduction of the duration of SWS episodes, but not the total number of SWS episodes and the prolonged latency of sleep.[D-Val5]NPS dosing at 20 nmol significantly antagonized the arousal promoting effect of 1 nmol NPS, but injected alone did not prolong SWS.Conclusion NPS significantly reduced anesthetics-induced SWS and EEG slow activities through selective stimulation of the NPSR and subsequent arousal pathways.
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