【摘 要】
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Background TMP an alkaloid extracted from Ligusricum wallichii Franchat (Apiaceae),has been widely used in traditional Chinese medicine for the treatment of cardiovascular and neurovascular diseases.O
【机 构】
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Nanjing General Army Hospital,Nanjing 210002,China
【出 处】
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第十二届中国介入心脏病学大会(CIT2014)
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Background TMP an alkaloid extracted from Ligusricum wallichii Franchat (Apiaceae),has been widely used in traditional Chinese medicine for the treatment of cardiovascular and neurovascular diseases.Observe the protective effect of ligustrazine to hearts subject to IR injury (through evaluating myocardial enzyme,infarct size,electron microscopic structure,inflammatory reaction and apoptosis) and whether the protective effect of ligustrazine is dose-related.Discuss the protective mechanism of ligustrazine: the role of phosphatidylinositol 3-kinase (PI3K)/Akt pathway in IR injury protection,the role of phosphorylation of the downstream target of PI3K/Akt-eNOS and production of NO in the anti-apoptotic and anti-inflammatory effect of TMP.
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