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目的:探讨核周型抗中性粒细胞胞浆抗体(P-ANCA)在狼疮性肾炎(LN)中的临床意义。方法:应用酶联免疫吸附分析(ELISA)的方法,检测92例LN患者血清中的P-ANCA及其他自身抗体的水平,并进一步分析P-ANCA与LN的临床表现以及辅助检查结果之间的关系。结果:P-ANCA在LN中的阳性率是21.8%(20/92),P-ANCA阳性组LN患者合并颧部红斑、皮肤血管炎、贫血以及补体C3偏低的频率均显著高于P-ANCA阴性组LN患者(P<0.05)。结论:P-ANCA在LN中的阳性率为21.8%,且P-ANCA与SLE特定的临床表现相关,提示P-ANCA可能参与了LN的发病过程。
Objective: To investigate the clinical significance of perinuclear anti-neutrophil cytoplasmic antibody (P-ANCA) in lupus nephritis (LN). Methods: Serum levels of P-ANCA and other autoantibodies in 92 patients with LN were detected by enzyme-linked immunosorbent assay (ELISA), and the clinical manifestations of P-ANCA and LN were analyzed. relationship. Results: The positive rate of P-ANCA in LN was 21.8% (20/92). The frequency of erythema in malar complex, skin vasculitis, anemia and complement C3 in P-ANCA positive patients was significantly higher than that in P- ANCA-negative LN patients (P <0.05). Conclusion: The positive rate of P-ANCA in LN was 21.8%. P-ANCA correlated with the specific clinical manifestations of SLE, suggesting that P-ANCA may be involved in the pathogenesis of LN.