环境致癌代谢物BPDE导致女性滋养层细胞功能障碍的分子机制研究

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：lwllwl200315

【摘要】

：

苯并芘(BaP)是多环芳烃中的典型代表,广泛存在于各种环境中,在体内可代谢为BPDE,导致各种毒性.BaP可引起子痫、子宫内生长受限、流产等相关疾病.在胚胎发育过程中,绒毛膜外滋养层细胞迁移并侵袭子宫蜕膜.侵袭迁移不足将引发子痫前期(PE)、子痫等不良妊娠结局；而过度侵袭则会引发侵袭性葡萄胎和绒毛膜癌等疾病.目前,关于BaP是否会影响滋养层细胞的功能、迁移和侵袭能力、以及相应的分子机制并不清楚.

【作者】

：

张慧东

【机构】

：

四川大学华西公共卫生学院,成都,610041

【出处】

：

中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

女性滋养层细胞HTR8/SVneo和Swan71 环境致癌物BPDE 迁移侵袭线粒体分裂融合

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环境致癌代谢物BPDE导致女性滋养层细胞功能障碍的分子机制研究

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