【摘 要】
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Objective: We are aim to identify some certain proteins that are related to breast cancer metastasis and evaluate the relationship between nucleobindin-2 (NUCB2) and prognosis of patients with breast
【机 构】
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Department of Pathology,Hunan Cancer Hospital & the Affiliated Cancer Hospital of Xiangya School of
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Objective: We are aim to identify some certain proteins that are related to breast cancer metastasis and evaluate the relationship between nucleobindin-2 (NUCB2) and prognosis of patients with breast cancer.Methods: We applied iTRAQ proteomic technique to screen differentially expressed proteins in 23 primary breast cancer tissues and paired metastatic lymph nodes samples,and evaluated NUCB2 expression in 50 benign breast disease samples,189 primary breast cancer samples (83 patients without metastases and 106 patients with lymph nodes metastases) and 106 paired metastatic lymph nodes by using immunohistochemistry.In addition, the correlation of NUCB2 protein expression with clinicopathological parameters was assessed by x2 analysis.Kaplan-Meier analysis and Cox regression models were used to investigate the relationship between NUCB2 protein expression and prognosis of breast cancer patients.
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