【摘 要】
：
单壁碳纳米角(Single-wall carbon nanohorns,SWNHs)在合成过程中不需使用金属催化剂催化,使其表现出低毒性；同时,其能有效地将近红外光转换成热,是一种理想的纳米光热试剂[1]。然而,水溶性差、靶向性缺乏的不足严重限制了它在生物医学上的实际应用。二氢卟吩e6(Chlorine e6,Ce6)具有高的单线态氧量子产率,可以被用于光动力治疗肿瘤,但其在血液中易被清除的不足限
【机 构】
：
药用资源化学与药物分子工程省部共建国家重点实验室,广西师范大学化学与药学学院,桂林,541004
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单壁碳纳米角(Single-wall carbon nanohorns,SWNHs)在合成过程中不需使用金属催化剂催化,使其表现出低毒性；同时,其能有效地将近红外光转换成热,是一种理想的纳米光热试剂[1]。然而,水溶性差、靶向性缺乏的不足严重限制了它在生物医学上的实际应用。二氢卟吩e6(Chlorine e6,Ce6)具有高的单线态氧量子产率,可以被用于光动力治疗肿瘤,但其在血液中易被清除的不足限制了它的实际应用[2]。在此,我们通过一步超声法将Ce6 修饰的透明质酸(hyaluronicacid,HA)与SWNHs 进行复合,制备用于靶向光热/光动力联合治疗肿瘤的SWNHs/Ce6-HA 纳米复合物。在SWNHs/Ce6-HA 中,SWNHs 作为药物载体能有效增强Ce6 的血液循环能力；HA 不仅能改善SWNHs 水溶性,而且赋予复合物靶向CD44 过表达癌细胞的能力[3]。此外,Ce6-HA 的HA 骨架能被细胞内透明质酸酶有效降解,从而恢复Ce6 荧光以实现诊断成像。综上所述,我们成功构筑一种能被用于荧光成像介导的多功能靶向肿瘤光治疗碳基纳米平台。本研究的开展为构建新型表面多功能精准化的碳基光诊疗纳米材料提供了实验基础。
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