LSD1(Histone lysine specific demethylase 1)was the first identified histone demethylase,which can demethylate mono-,di-methylation of H3K4 and H3K9 as well as other non-histone substrates.
Chemical modifications on the steroid nucleus have been recognized as efficient strategies to access steroidal derivatives with biological potential.
手性是自然界普遍存在的现象,手性药物通常是指组成原子相同,但立体结构呈镜像关系的药物。已上市的药物中,天然或半合成药物几乎都有手性,98％以上为光学活性物质；全合成药物中40％为手性药物,目前常用的 700 多种药物至少一半含有手性中心[1]。
目的 体外建立人食管癌耐紫杉醇细胞株TE-1/Taxol,考察其生物学特性,研究紫杉醇耐药的发生机制,为临床预防紫杉醇耐药提供理论依据。
组蛋白是真核生物染色质的碱性蛋白，翻译后能够有许多种化学修饰如：甲基化、乙酰化、磷酸化、泛素化、sumo 化以及APD 核糖糖基化等。组蛋白赖氨酸特异性去甲基化酶1(LSD1)，在FDA 的参与下，在体外可以特异去掉H3K4 的双甲基和单甲基修饰，在体内则可以去掉H3K9 的双甲基和单甲基修饰。
野菊花中黄酮类化合物种类繁多,具有提高免疫力、抗氧化活性、抗炎等作用。运用荧光光谱法探究野菊花中木犀草素、芹菜素、刺槐素、麦黄酮、5,3,4-三羟基-6,7-二甲氧基黄酮、5,7,4-三羟基-6,3,5-三甲氧基黄酮、蒙花苷等7 种黄酮类化合物与牛血清白蛋白(BSA)相互作用,从分子水平上阐明其作用机制,研究相互作用能力与取代基种类、数目、位置的关系。
As a pivotal factor in the signal transduction pathways,protein tyrosine kinases(PTKs)is highly related with the oncology such as non-small cell lung cancer,breast cancer,colon cancer,etc[1].
Phthalazine showed a series of biological activities,such as reduce blood press,antimicrobial,anticancer,antiinflammatory and antiepileptic[1].
Studying on the medicinal value and the SAR of natural compounds and their derivatives is one of the most important methods in the research and development of new drugs[1].