【摘 要】
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Nanogels are nanometer sized hydrogel nanoparticles formed by physically or chemically cross-linked polymer networks.They are very promising as drug delivery carriers because of their high hydrophily,
【机 构】
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Schoolof Materials Science and Engineering, Shanghai University, Shanghai 200444
【出 处】
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第十五届上海地区医用生物材料学术研讨会
论文部分内容阅读
Nanogels are nanometer sized hydrogel nanoparticles formed by physically or chemically cross-linked polymer networks.They are very promising as drug delivery carriers because of their high hydrophily, high surface area, and responsiveness to environmental factors.However, there are a few deficiencies with nanogels such as insufficient control over size and low drug loading.In this study, SiO2 nanospheres were used as templates and poly(L-glutamic acid)(PLGA) was grafted to the surface, then PLGA/CS hollow nanogels were obtained by choosing chitosan(CS) as macromolecular crosslinking agent.The preparation, influence factors on size, intelligent responses, loading capacity as well as release of drug of PLGA/CS hollow nanogels were researched in detail in this paper.
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