【摘 要】
：
Apoptosis induced by microbial infections are factors implicated in the pathogenesis of Helicobacter pylori (H.pylon) infection.Here we show that human gastric epithelial cells sensitized to H.pylori
【机 构】
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Graduate Institute of Immunology,College of Medicine,National Taiwan University.Taipei,Taiwan
【出 处】
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第六届海峡两岸生物医学和生物工程学术会议
论文部分内容阅读
Apoptosis induced by microbial infections are factors implicated in the pathogenesis of Helicobacter pylori (H.pylon) infection.Here we show that human gastric epithelial cells sensitized to H.pylori confer susceptibility to TRAIL-mediated apoptosis.Human gastric epithelial cells were resistant to TRAIL despite expression of TRAIL death receptors and induction of caspase-8 activation after TRAIL engagement.However,in the presence of H.pylori,TRAIL induces sequential activation of caspase-8,Bid cleavage,activation of mitochondrial pathway,leading to breaking apoptosis resistance.The H.pylori-induced TRAIL sensitivity could be blocked by capsase-9 inhibitor and overexpression of Bcl-2,indicating mitochondrial pathway is required for apoptosis signaling.Therefore,the induction of TRAIL sensitivity by H.pylori is dependent on activation of caspase-8 downstream pathway to convey the death signal to mitochondria,leading to activation of mitochondrial signaling pathway and breaking apoptosis resistance.Modulation of host apoptosis signal transduction by bacterial interaction adds a new dimension to the immune pathogenesis in Helicobacter infection.
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