【摘 要】
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Self-assembled nanoparticles composed of amphiphilic block copolymers can efficiently encapsulate hydrophobic anticancer drugs into the hydrophobic core.As demonstrated in the phase 1 clinical data of
【机 构】
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School of Medical Engineering,Hefei University of Technology,Hefei 230009,China
【出 处】
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The Third Symposium on Innovative Polymers for Controlled De
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Self-assembled nanoparticles composed of amphiphilic block copolymers can efficiently encapsulate hydrophobic anticancer drugs into the hydrophobic core.As demonstrated in the phase 1 clinical data of BIND-014,the release rate of encapsulated drug depended on the composition of the hydrophobic core of the nanoparticles [1].The intracellular drug release rate from the hydrophobic core of self-assembled nanoparticle significantly affected the therapeutic efficacy.However,the hydrophobic core of current polymeric nanoparticles usually is in the glassy or crystalline state at room temperature,which may hinder the diffusion of drug from the core.In contrast,polyphosphoesters (PPEs) are at the viscous flow state at room temperature.Therefore,the molecular motions were significantly increased compared to the commonly used materials,which may improve the drug release from the PPE core.The use of PPE as the core of self-assembled nanoparticles for cancer therapy has rarely been reported.
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