【摘 要】
：
Drug metabolizing enzymes (DMEs) play important roles in mammalians for the synthesis, metabolism and excretion of various kinds of chemicals, including num
【机 构】
：
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics,Chinese Academ
【出 处】
：
2015年第一届药代动力学朝阳论坛
论文部分内容阅读
Drug metabolizing enzymes (DMEs) play important roles in mammalians for the synthesis, metabolism and excretion of various kinds of chemicals, including numerous therapeutic agents, food chemicals, environmental toxins and endogenous substrates.The distribution and functions of DMEs differ among various species or individuals, due to the genetic polymorphism and the different response to environmental, hormonal, or nutritional influences.Discovery of specific probe substrates which can precisely measure the real function of a given DME in complex biological systems would be of tremendous benefit to the drug metabolism related fields.
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