A mild and efficient reaction of [2,3]-sigmatropic rearrangement of quaternary buta-2,3-dien ammonium ylides via in situ activation of tertiary buta-2,3-dien amines with arynes has been developed.
Structurally modified nucleosides attract synthetic and biological interest because selective compounds are vulnerable to treating diseases where the normal state differs from the diseased state regar
Transition metal catalyzed radical cross-coupling(RCC)reactions represent a robust,new tool for the construction of C-C and C–heteroatom bonds.1 In this context,despite the extensive utility of alkyl
Quinolines are privileged aromatic aza-heterocycles found in wide range of natural product.1 Povarov reaction is the most effective,enabling the rapid assembly of quinolones.However,recent progress in
Recently,many groups have made great contributions on the transfer of sulfur salts.1 However,contributions in this field were mainly focused on using sulfur salts as simple sulfur source to form S-con
靛红是一种从菘蓝属植物中提取出的双环小分子天然产物。由于受到自身羰基与γ-内酰胺基团的影响，靛红具有多个反应位点，表现出多重反应性，同时，由于其具有合成简易，来源广泛，价格低廉等优点，因此靛红及其衍生物作为一类重要合成子的应用一直以来也是有机合成的研究重点之一。
Herein,we disclosed a molecular iodine-mediated formal [2+1+1+1] cycloaddition reaction for the construction of pyrrolo[2,1-a]isoquinolines.This new reaction involves intermolecular cycloaddition of t
喹啉及其衍生物是一类具有广泛生物活性的含氮杂环化合物,研究表明,该类化合物有抗菌[1]、抗HIV-1、抗结核[2]等活性.其中一些化合物还具有抗肿瘤活性,有望成为新的抗癌药物.1,2,3-三氮唑类化合物具有较好的抗真菌、抗肿瘤和抗炎等活性[3].因此,我们利用活性片段拼接的方式,以喹啉环为骨架,设计合成了一系列含1,2,3-三氮唑的衍生物,初步的测试表明此类化合物具有一定的生物活性.
吲哚里西啶类生物碱具有很好的生物活性,因此该类生物碱的高效合成受到广泛关注.1过渡金属催化的碳胺化反应为结构复杂的氮杂多环类化合物的合成提供了一种可能的途径.过渡金属催化烯烃的碳胺化反应是指在反应过程中同时形成新的C-N键和C-C键的反应,2该反应可用于吲哚里西啶类生物碱的构建.本文以三氟甲磺酸铜(10 mol％)为催化剂,实现了烯胺1的分子内碳胺化反应,构建了吲哚里西啶类产物2(图1).该方法操