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The increasing resistance of bacteria and fungi to currently available antibiotics is a major concern world-wide,leading to enormous effort to develop novel antibiotics with new modes of action.We recently reported that ABP-dHC-cecropin A exhibited strong antibacterial and antifungal activity,making it a candidate antibiotic substitute.In this study,β-cyclodextrin(β-CD)combined with ABP-dHC-cecropin A enhanced the physical and chemical properties of ABP-dHC-cecropin A but did not significantly decrease its antibacterial activity.