Purpose To compare choroidal microstructural changes in eyes with age-related macular degeneration(AMD)of different stages.Design Retrospective,cross-sectional case series.Participants Thirty-two age-
Purpose To describe a use of a newly developed micro probe endoscopic swept-source optical coherence tomography(SS-OCT)system to achieve ex vivo imaging of collector channels(CCs).Methods The system w
Purpose The clinical phenotype of retinal gliosis occurs in different forms; here,we characterize one novel genetic feature,i.e.signaling via BMP-receptor 1b.Methods Mouse mutants were generated withi
Zinc(Zn),the second abundant trace element in living organisms,plays an important role in regulating cell metabolism,signaling,proliferation,gene expression and apoptosis.Meanwhile,the overload of Zn
目的 将分离的皮肤干细胞作为种子细胞体外诱导其分化为角膜内皮样细胞,以寻求角膜内皮细胞失代偿新的治疗方法。方法 分离培养皮肤干细胞,层粘连蛋白、硫酸软骨素一定比例包被培养板后将皮肤干细胞接种,用B4G12 细胞条件培养基法和transwell 小室共培养法将皮肤干细胞诱导为角膜内皮样细胞,探寻较好的诱导方案;PCR鉴定角膜内皮样细胞Na-K ATPase alpha1,ZO-1,CA2,Col8a
目的 miRNAs 在很多病理生理过程中发挥重要作用,包括病理性血管生成、氧化应激反应、免疫反应和炎症等。氧化应激是引起视网膜变性的主要原因之一,是糖尿病视网膜病变(简称糖网病)、早产儿视网膜病变和年龄相关性黄斑变性发病的重要环节。
目的 构建贝伐单抗纳米粒/聚乙烯醇复合膜片应用于眼表新生血管治疗。方法 利用自组装技术制备贝伐单抗纳米粒,流延法制备贝伐单抗纳米粒/聚乙烯醇复合膜片。采用碱烧伤法制备大鼠新生血管模型。造模后结膜囊内放置直径2mm载药复合膜片,以空白膜片加贝伐单抗滴眼液作为对照组。
目的 本文主要研究的是晶状体内晚期糖基化终末产物与糖尿病病情的相关性。方法 选取的入组患者为2015 年9 月至2015 年12 月就诊于沈阳何氏眼科医院,共100 例。根据有无已确诊的糖尿病分为无糖尿病组(NDM 组),共40 名,及有糖尿病组(DM 组),共60 例。
Objective Elevation of intraocular cAMP facilitates neuronal survival in CNS.Papaverine is an panphosphodiesterase inhibitor which could inhibit the degradation of intracellular cAMP.The aim of this s
Purpose The aim of this investigation was to investigate whether a PVCL-PVA-PEG nanomicelle formulation could overcome some of the obstacles presented by topical ophthalmic curcumin formulations and p