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  5. Amphiphilic block copolymer of SN38 prodrugs by atom transfer radical polymerization: synthesis, kin

Amphiphilic block copolymer of SN38 prodrugs by atom transfer radical polymerization: synthesis, kin

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：prcjzzz
【摘 要】
：
Modification of anti-cancer drugs with poly(ethylene glycol)(PEG),e.g.directly linking PEG to hydrophobic drugs and conjugating drugs to PEG-block copolymers (PEG-polyDeug),has been shown to significa
【作 者】
：
Xun Liu Jinqiang Wang Youqing Shen Jianbin Tang Meihua Sui 
【机 构】
：
Key Laboratory of Biomass Chemical Engineering of Ministry of Education,Center for Bionanoengineerin
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
amphiphilic copolymer atom transfer radical polymerization SN38 nanoparticles 
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　　Modification of anti-cancer drugs with poly(ethylene glycol)(PEG),e.g.directly linking PEG to hydrophobic drugs and conjugating drugs to PEG-block copolymers (PEG-polyDeug),has been shown to significantly improve the physicochemical and biological properties of various drug delivery systems [1].PEG-polyDrugs are generally synthesized by conjugating anticancer drugs via cleavable bonds onto the polymer backbones.However,this method has several disadvantages including incomplete conjugation,side reactions and broad polydispersity.
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