【摘 要】
：
Objective: To explore whether neutrophil gelatinase-associated lipocalin (NGAL) could be used to predict the progression of diabetic nephropathy in type 2 diabetic patients, and whether telmisartan ca
【机 构】
：
The 2nd affiliated Hospital of Shantou University Medical College China
【出 处】
：
2013第三届内分泌与代谢大会暨2013第二届糖尿病大会
论文部分内容阅读
Objective: To explore whether neutrophil gelatinase-associated lipocalin (NGAL) could be used to predict the progression of diabetic nephropathy in type 2 diabetic patients, and whether telmisartan can help to explore the main cause of NGAL change.Method:74 type 2 diabetic patients were divided into three groups according to their 24 h-urinary albumin excreting rate.A prospective controlled trial that treated with telmisartan for a random time lasting for 3 or 12 months can help to explore the main cause of NGAL change.68 patients accomplished in a second prospective controlled trial, and 43 of them were treated with telmisartan, 25 were used as control.Urine NGAL (uNGAL) and Serum NGAL (sNGAL) were quantified by ELISA.Results: An increased tendency of uNGAL and a decreased of sNGAL were detected, from normoalbuminuria group to macro-albuminuria group.sNGAL rise after follow-up.There is a strong correlation between sNGAL and uNGAL.The correlation differed in different period of DN and changed after telmisartan treament.Conclusion: sNGAL may be more useful in early detection and uNGAL may be more meaningful in renal function assessment.The contraction of sNGAL might be relating to the rise of eGFR in type 2 diabetic patients with microalbuminuric nephropathy.Telmisartan plays an important role in improving glomerular filtration and tubular reabsorption.
其他文献
Acupuncture exerts cardioprotective effects on several types of cardiac injuries, especially myocardial ischemia (MI), but the mechanisms have not yet been well elucidated.Angiogenesis mediated by VEG
Dill or Anethum graveolens Linn.is reputed for skin tonic, anti-inflammation and wound healing effect.Therefore, we aimed to determine the wound healing and anti-dermatitis effects of dill.In this stu
Nonhuman primates (NHPs) share similarities in metabolism and metabolic disease progression path with human.Therefore, developing a metabolic diseases NHP model with excess nutrients and inactivity, t
We aim to understand how various organs and tissues in the body coordinate the complex metabolic networks and circuitry to maintain proper energy balance, failure of which results in metabolic disorde
During fasting, induction of hepatic gluconeogenesis is important to ensure energy homeostasis in response to the energy demand.However, such induction is dysregulated in type 2 diabetes, resulting in
The incidence of Type 1 diabetes has increased tremendously in Sweden during the last twenty years.One obvious environmental factors coinciding with this increase is the radical changes of food habits
Obesity-induced inflammation causes insulin resistance, type 2 diabetes, and the metabolic syndrome.A significant advance in our understanding of obesity-associated inflammation and insulin resistance
Obesity and diabetes mellitus (DM) have increased in dogs and cats, and cats tend to fall in insulin resistance and type 2 DM (T2DM) with ease compared to dogs.In dogs type 1 DM (T1DM) appears to be t
Diabetic nephropathy is a common diabetic microvascular complication.Recently, several studies have demonstrated that the changes ofhistone modifications are linked to the development of diabetic neph
Metabolic syndrome is a combination of medical disorders including visceral obesity, hypertension, glucose intolerance and dyslipidemia, which are great risk factors for chronic kidney disease.Diabeti