【摘 要】
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Background Ursodeoxycholic acid (UDCA) is an effective medical therapy for patients with primary biliary cirrhosis (PBC) ; however, 40％ of PBC patients showing an incomplete response to UDCA therapy.T
【机 构】
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Beijing 302 hospital
【出 处】
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中华医学会第十六次全国病毒性肝炎及肝病学术会议
论文部分内容阅读
Background Ursodeoxycholic acid (UDCA) is an effective medical therapy for patients with primary biliary cirrhosis (PBC) ; however, 40％ of PBC patients showing an incomplete response to UDCA therapy.This study aimed to investigate the safety and efficacy of umbilical cord-derived mesenchymal stem ceil (UCMSC) transfusion in PBCpatients with incomplete response to UDCA.Methods We conducted a single-arm trial that involved seven PBC patients with a suboptimal response to UDCA treatment.UC-MSCs were first cultured, and then 0.5 × 106 cells/kg body weights were infused through a peripheralvein.UC-MSCs were giventhree times at 4-week intervals, and patients were followed up for 48 weeks.
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