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microRNAs biogenesis has been finely controlled by complex layers of post-transcriptional regulations,including RNA-binding proteins(RBPs).Here we showed an RNA binding protein,QKI5,orchestrated the maturation of primary miR-124-1(pri-124-1),transcriptionally activated by GATA-1,resulting in no accumulation of the final product miR-124-1 during erythropoiesis.