【摘 要】
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Though great attention has been paid in constructing well-defined nano-structures via the self-assembly of amphiphilic macromolecules,the self-assembly of non-amphiphilic macromolecules in nanodroplet
【机 构】
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CAS Key Laboratory of Soft Matter Chemistry,Department of Polymer Science and Engineering,University
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Though great attention has been paid in constructing well-defined nano-structures via the self-assembly of amphiphilic macromolecules,the self-assembly of non-amphiphilic macromolecules in nanodroplets has drawn less attention up to now.We prepared a temperature-responsive PEG-based branched polymer with disulfide bonds in its backbone via reversible addition–fragmentation chain transfer(RAFT)polymerization of 2-(2-methoxyethoxy)ethyl methacrylate,oligo(ethylene glycol)methacrylate,and N,N-cystamine bisacrylamide.When the polymer was restricted within nanodroplets,it can self-assemble into nanocapsules,which cannot be obtained via its assembly in solution.The advances of this method is that the nanostructures can be produced in a large scale and controlled size,and nanocapsules can load drug molecules,protein,and even large-sized plasmid DNA efficiently,then deliver the loaded molecules into living cells.
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