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儿童激素性股骨头坏死是由于糖皮质激素通过多途径破坏儿童股骨头的局部血供,从而引起以骨小梁和骨髓局部坏死为特征的疾病。摄入充足的钙和维生素D_3是预防本病的基础。本文介绍儿童激素性股骨头坏死的发病机制和影响因素。探索应用钙剂和维生素D_3制剂预防长期应用糖皮质激素患儿发生儿童激素性股骨头坏死的给药方案。总结文献经验,在给药时机、给药剂量和防止药物不良反应方面,提供用药参考。
Hormonal osteonecrosis of the femoral head is a disease characterized by glucocorticoid disrupting the local blood supply of the child’s femoral head via multiple routes, causing localized trabecular and bone marrow necrosis. Adequate intake of calcium and vitamin D_3 is the basis for the prevention of this disease. This article describes the pathogenesis and influencing factors of steroid-induced femoral head necrosis in children. To explore the application of calcium and vitamin D_3 preparations to prevent children with steroid-induced osteonecrosis of the femoral head in long-term application of glucocorticoid. Summarize the literature experience, in the timing of drug delivery, dosage and prevent adverse drug reactions, provide medication reference.