Objective: To evaluate the incidence and predisposing factors of mesh-related complications.Methods: Retrospective chart review of patients with cervical cancer (stages ⅠA2-ⅡB) who underwent radical hysterectomy and pelvic lymphadenectomy from 2005 to 2012.Methods: In this prospective cohort study,206 consecutive patients with advanced pelvic organ prolapse (POP) underwent Prolift mesh kit surgical repair and were followed for 6 years.Postoperative voiding difficulty,mesh-related complications,pain and recurrence were evaluated.Voiding difficulty was defined as a post-void bladder volume ≥ 100 ml or greater than 1/3 of the voided volume.Recurrence was considered symptomatic POP-Q stage ≥ Ⅱ.The IUGA/ICS joint terminology was used for mesh-related complications.Multivariate logistic regression was used for data analysis.Results: Fourteen patients were lost to follow-up.Postoperative voiding difficulty occurred in 60/192 patients (31.25%); 85% (51/60) reported symptom resolution within 3 days.Patients with ≥200 ml residual urine volume experienced more difficult recovery (P=0.01).Low preoperative average urine flow and residual urine were independent risk factors (OR=4.7,95% CI 1.3-17.2; OR=2.6,95% CI 1.3-5.0).Meshrelated complications were reported in 29/192 (15.1%),and vaginal complication accounted for 69.0% (20/29).High blood loss (OR=5.8,95% CI 1.8-18.3) and pelvic surgery history (OR=5.5,95% CI 1.2-25.1) were strongly related to complications.Postoperative pain was reported by 10/192 (5.2%) patients and was closely related to vaginal complications.Additionally,97.9% (188/192) of patients exhibited successful anatomical outcomes.The small patient sample prevented the analysis of pain and recurrence.Conclusion: Vaginal complications are the main complications.Greater blood loss and pelvic surgery history are predictive of it.Low average urine flow rates and preoperative urinary retention are predictive of postoperative voiding difficulty.