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目的:过度磷酸化的Tau蛋白聚集在神经元内形成的神经元纤维缠结是阿尔茨海默病的主要病理变化.近年来许多研究证明AD患者早期线粒体出现线粒体分布和功能障碍可能参与其早期发病机制.
DLP1和PP2AC下调参与tau蛋白诱导的细胞线粒体分布异常
【摘 要】
：
目的:过度磷酸化的Tau蛋白聚集在神经元内形成的神经元纤维缠结是阿尔茨海默病的主要病理变化.近年来许多研究证明AD患者早期线粒体出现线粒体分布和功能障碍可能参与其早期发病机制.
【机 构】
：
三峡大学医学院病理生理教研室 湖北宜昌443002
【出 处】
：
第八届全国医学生物化学与分子生物学、第五届全国临床应用生物化学与分子生物学、2013华东六省一市生物化学与分子生物学联合
【发表日期】
：
2013年2期
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