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用不同剂量的干甲状腺片治疗40例原发性甲状腺机能减低症,观察其血清TSH、T_4及T_3含量的变化。发现替代治疗后,疗效与干甲状腺片用量密切相关,其血清TSH及T_4值的变化与用药量和临床表现基本一致。血TSH与T_4值之间呈显著负相关。作者认为适当的替代剂量不仅根据临床表现,而更应根据血清的 TSH、T_4及T_3水平来判定。
Treatment of 40 cases of primary hypothyroidism with different doses of dry thyroid tablets to observe the changes of serum TSH, T 4 and T 3 levels. Found that replacement therapy, the effect is closely related with the amount of dry thyroid tablets, the changes in serum TSH and T_4 values and the dose and clinical manifestations are basically the same. There was a significant negative correlation between serum TSH and T_4. The author believes that the appropriate alternative dose not only based on clinical manifestations, but should be based on serum levels of TSH, T_4 and T_3 to determine.