Diabetic nephropathy(DN)is a serious microvascular complication that can lead to chronic and end-stage renal failure.It is understood that inflammation is associated with the onset and process of DN.
Galectin-3(Gal-3)has been implicated in pancreatic ductal adenocarcinoma(PDAC),and its candidacy as a therapeutic target has been evaluated.Gal-3 is widely up-regulated in tumors,and its expression is
糖蛋白糖链的结构分析对深入了解糖链的生物学功能、发现新的疾病标志物和疫苗的开发都具有十分重要的意义。针对天然糖链及其异构体分离选择性不足和低丰度糖链结构分析困难等问题,本研究以模式糖蛋白-鸡卵清蛋白(OV)为研究对象,首先采用非特异性蛋白酶Pronase E 实现其糖链的释放,得到只连接一个天冬酰胺(Asn)的N-糖链。
The peptidoglycan hydrolase DacB plays a key role in the remodeling of Streptococcus pneumoniae peptidoglycan during cell division.To decipher the substrate-binding property and catalytic mechanism,he