Background:The side population cells characterized by the ability to transport Hoechst 33342 out of cells have been identified as cancer stem-like cells.ABCG2 is found to confer the side population (S
目的 雷公藤是一种疗效卓越的传统中药,但由于其毒性较大,且作用机制不清,限制了在临床上的应用.在本研究中,我们致力于寻找高效低毒的具有明显抗肿瘤作用的雷公藤内酯醇衍生物,研究其作用机制,并在此基础上设计联合用药方案,寻找新的肿瘤治疗策略.
In recent years,"compact molecules" e.g.4-membered hetereocyclic compounds have received increased attention in pharmaceutical industry because of the uniqueness in the generation of IP position,as we
Purpose Activating mutations of c-Kit have been associated with gastrointestinal stromal tumors (GISTs).Unfortunately,primary or acquired resistance to c-Kit inhibitors,such as imatinib and sunitinib,
Object Photodynamic therapy (PDT) is a regulatory approved modality for treating a variety of malignant.It utilizes the destructive power of reactive oxygen species generated via visible light irradia
Object Colorectal carcinoma is a frequent cause of cancer-related death in men and women.miRNAs (microRNAs) are endogenous small non-coding RNAs that regulate gene expression negatively at post-transc
畲药白山毛桃根是少数民族畲族常用药物,具有清热解毒,消肿利湿的功效,民间主要用于治疗胃癌、肠癌、白血病、肝硬化等疾病.但是,对于其确切疗效及其可能的机制,目前缺乏实验研究依据.黑色素瘤是一种恶性程度较高、死亡率高的肿瘤,尚无有效的治疗方法.黑色素瘤细胞株M21细胞是国内外研究黑色素瘤的常用细胞株.本课题对畲药白山毛桃根的有效成分进行提取收集,以M21细胞为研究对象,采用体外细胞培养系统,观察畲药白
Background To validate cadherin-17 (CDH 17) as a potential therapeutic target for gastric cancer (GC) and to investigate the antitumor mechanisms associated with CDH17 inhibition in GC.Methods GC tiss
Purpose The aim of this study is to explore the mechanisms of the cancer cell resistance toward dihydroartemisinin (DHA),one of the main metabolites and derivatives of artemisinin,which has exhibited
目的 原纤毛是以微管为结构基础并突出于细胞表面的"天线状"细胞器,其结构和功能异常与肿瘤发生发展密切相关.文献报道,NEK-8参与调控原纤毛结构,但其自身表达和活性调控机制、及其调控原纤毛结构的机制均有待于进一步研究.我们首次发现pVHL参与NEK-8的表达调控,并将探讨相关机制.